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Chokepoint Reaction Finder

Include reactions found in human
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Include reactions catalyzed by more than one enzyme
Exclude reactions catalyzed by more than one enzyme

Include all reactions
Limit to reactions found in multiple pathways

Definition: A chokepoint reaction is a reaction that is either the unique consumer of a given metabolite (the only reaction consuming that metabolite), or is the unique producer of a metabolite. That metabolite must have at least one reaction that consumes it and at least one reaction that produces it (in other words, the metabolite must not be a dead-end). In theory, chokepoint reactions make good drug targets because disabling that reaction disrupts the only path to or from a metabolite.

The definition of a chokepoint used here was derived from: Genome Research 14:917 (2004) "Computational analysis of Plasmodium falciparum metabolism: Organizing genomic information to facilitate drug discovery". [Pubmed].

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