MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
UDP-glucuronosyltransferase 2B7 : UGT2B7 ( Homo sapiens )

Supersedes EC numbers:,

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glucuronosyltransferase

Enzyme Commission Synonyms: 1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17β-hydroxysteroid UDP-glucuronosyltransferase, 3α-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDPGT, bilirubin glucuronyltransferase, ciramadol UDP-glucuronyltransferase, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase, uridine diphosphoglucuronate-estriol glucuronosyltransferase, uridine diphosphoglucuronate-estradiol glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16α-glucuronosyltransferase, GT, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyltransferase, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPGT, uridine diphosphoglucuronyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphoglucuronosyltransferase

Taxonomic Range: Viridiplantae , Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): -74.36896 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC, EC, EC, EC, EC, EC, EC and EC A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in [Bock83].

Citations: [Bock79, Green85, Burchell81, Dutton80, Jansen74]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01383

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:P06133 , UniProt:RELATED-TO:P08430 , UniProt:RELATED-TO:P08541 , UniProt:RELATED-TO:P09875 , UniProt:RELATED-TO:P16662 , UniProt:RELATED-TO:P17717 , UniProt:RELATED-TO:P19224 , UniProt:RELATED-TO:P19488 , UniProt:RELATED-TO:P20720 , UniProt:RELATED-TO:P22309 , UniProt:RELATED-TO:P36511 , UniProt:RELATED-TO:P36512 , UniProt:RELATED-TO:P36513 , UniProt:RELATED-TO:P54855 , UniProt:RELATED-TO:Q7BLV3 , UniProt:RELATED-TO:Q9TR24 , UniProt:RELATED-TO:Q28611 , UniProt:RELATED-TO:Q64435 , UniProt:RELATED-TO:Q64550


Bock79: Bock KW, Josting D, Lilienblum W, Pfeil H (1979). "Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital." Eur J Biochem 98(1);19-26. PMID: 111930

Bock83: Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS, Siest G, Tephly TR (1983). "UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions." Biochem Pharmacol 32(6);953-5. PMID: 6404284

Burchell81: Burchell B (1981). "Identification and purification of multiple forms of UDP-glucuronosyltransferase." Rev. Biochem. Toxicol. 3 132.

Dutton80: Dutton GJ (1980). "Glucuronidation of Drugs and Other Compounds." C.R.C. Press, Boca Raton, Florida.

Green85: Green MD, Falany CN, Kirkpatrick RB, Tephly TR (1985). "Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase." Biochem J 230(2);403-9. PMID: 3931633

Jansen74: Jansen PLM (1974). "The enzyme-catalyzed formation of bilirubin diglucuronide by a solublized preparation from cat liver microsomes." Biochim. Biophys. Acta 338 170-182.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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