|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Homo sapiens:||UDP-glucuronosyltransferase 2B7: UGT2B7|
Supersedes EC numbers: 18.104.22.168, 22.214.171.124
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: glucuronosyltransferase
Enzyme Commission Synonyms: 1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17β-hydroxysteroid UDP-glucuronosyltransferase, 3α-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDPGT, bilirubin glucuronyltransferase, ciramadol UDP-glucuronyltransferase, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase, uridine diphosphoglucuronate-estriol glucuronosyltransferase, uridine diphosphoglucuronate-estradiol glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16α-glucuronosyltransferase, GT, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyltransferase, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPGT, uridine diphosphoglucuronyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphoglucuronosyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -74.36896 [Latendresse13]
Enzyme Commission Summary:
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 126.96.36.199, EC 188.8.131.52, EC 184.108.40.206, EC 220.127.116.11, EC 18.104.22.168, EC 22.214.171.124, EC 126.96.36.199 and EC 188.8.131.52. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in [Bock83].
Unification Links: KEGG:R01383
Relationship Links: BRENDA:EC:184.108.40.206, ENZYME:EC:220.127.116.11, IUBMB-ExplorEnz:EC:18.104.22.168, UniProt:RELATED-TO:P06133, UniProt:RELATED-TO:P08430, UniProt:RELATED-TO:P08541, UniProt:RELATED-TO:P09875, UniProt:RELATED-TO:P16662, UniProt:RELATED-TO:P17717, UniProt:RELATED-TO:P19224, UniProt:RELATED-TO:P19488, UniProt:RELATED-TO:P20720, UniProt:RELATED-TO:P22309, UniProt:RELATED-TO:P36511, UniProt:RELATED-TO:P36512, UniProt:RELATED-TO:P36513, UniProt:RELATED-TO:P54855, UniProt:RELATED-TO:Q7BLV3, UniProt:RELATED-TO:Q9TR24, UniProt:RELATED-TO:Q28611, UniProt:RELATED-TO:Q64435, UniProt:RELATED-TO:Q64550
Bock79: Bock KW, Josting D, Lilienblum W, Pfeil H (1979). "Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital." Eur J Biochem 98(1);19-26. PMID: 111930
Bock83: Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS, Siest G, Tephly TR (1983). "UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions." Biochem Pharmacol 32(6);953-5. PMID: 6404284
©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493