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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.7.9

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.7.9

Enzymes and Genes:
UTP--glucose-1-phosphate uridylyltransferase Inferred from experiment : galU ( Escherichia coli K-12 substr. MG1655 )
N-acetylglucosamine-1-phosphate uridylyltransferase Inferred from experiment : AT2G35020.1 ( Arabidopsis thaliana col )
UDP-galactose/glucose pyrophosphorylase Inferred from experiment : UGGPase ( Cucumis melo )
UDP-glucose pyrophosphorylase Inferred from experiment : UGP1 ( Saccharomyces cerevisiae )
UDP-sugar pyrophosphorylase Inferred from experiment : AT5G52560 ( Arabidopsis thaliana col )
UDP-glucose pyrophosphorylase 2 Inferred by curator Inferred from experiment : Ugp2 ( Mus musculus )
UDP-glucose pyrophosphorylase Inferred from experiment : UGP2 ( Homo sapiens )
UDP-D-glucose pyrophosphorylase Inferred from experiment : USP ( Pisum sativum )
UDP-glucose pyrophosphorylase Inferred from experiment ( Cucumis melo )
UTP-glucose-1-phosphate uridylyltransferase Inferred from experiment : gtaB ( Bacillus subtilis )
UDP-glucose pyrophosphorylase Inferred from experiment : UGP ( Arabidopsis thaliana col )
UDP-glucose pyrophosphorylase Inferred from experiment : galU ( Mycoplasma pneumoniae M129 )
glucose-1-phosphate nucleotidyltransferase : jadQ ( Streptomyces venezuelae ATCC 10712 )

In Pathway: chitin biosynthesis , stachyose degradation , sucrose biosynthesis II , UDP-glucose biosynthesis , sucrose degradation II (sucrose synthase)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: UTP—glucose-1-phosphate uridylyltransferase

Enzyme Commission Synonyms: UDP glucose pyrophosphorylase, glucose-1-phosphate uridylyltransferase, UDPG phosphorylase, UDPG pyrophosphorylase, uridine 5'-diphosphoglucose pyrophosphorylase, uridine diphosphoglucose pyrophosphorylase, uridine diphosphate-D-glucose pyrophosphorylase, uridine-diphosphate glucose pyrophosphorylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -103.30347 Inferred by computational analysis [Latendresse13]

Citations: [Dai06, LobelleRich83, Kamogawa65, KALCKAR, SMITH55, Turnquist74]

Gene-Reaction Schematic: ?

Instance reactions of [α-D-glucose 1-phosphate + a nucleoside triphosphate + H+ → an NDP-α-D-glucose + diphosphate] (2.7.7.-):
i1: α-D-glucose 1-phosphate + GTP + H+ → GDP-α-D-glucose + diphosphate (2.7.7.34)

i2: α-D-glucose 1-phosphate + UTP + H+ ↔ UDP-α-D-glucose + diphosphate (2.7.7.9)
i3: α-D-glucose 1-phosphate + CTP + H+ ↔ CDP-α-D-glucose + diphosphate (2.7.7.33)

i4: α-D-glucose 1-phosphate + dTTP + H+ ↔ dTDP-α-D-glucose + diphosphate (2.7.7.24)

i5: α-D-glucose 1-phosphate + ATP + H+ → ADP-α-D-glucose + diphosphate (2.7.7.27)

Unification Links: KEGG:R00289 , PIR:A40650 , PIR:A41382 , PIR:A56146 , PIR:A64250 , PIR:A64970 , PIR:A75096 , PIR:D49349 , PIR:D69184 , PIR:D70601 , PIR:E64466 , PIR:E71913 , PIR:F59102 , PIR:F64600 , PIR:F81300 , PIR:G64095 , PIR:G70125 , PIR:H70446 , PIR:JC2265 , PIR:JC4785 , PIR:JC4985 , PIR:JX0277 , PIR:S15298 , PIR:S30007 , PIR:S31431 , PIR:S35692 , PIR:S41533 , PIR:S62599 , PIR:S73501 , PIR:S78541 , PIR:T42521 , PIR:T44841 , PIR:T45453 , PIR:XNDOU , PIR:XNPOU , Rhea:19889 , UniProt:O05576 , UniProt:O25363 , UniProt:O26731 , UniProt:O51225 , UniProt:O67602 , UniProt:P08800 , UniProt:P0AAB6 , UniProt:P0AEP3 , UniProt:P19595 , UniProt:P27897 , UniProt:P32861 , UniProt:P33696 , UniProt:P37776 , UniProt:P44878 , UniProt:P47691 , UniProt:P74969 , UniProt:P75124 , UniProt:P78811 , UniProt:Q9PMD3 , UniProt:Q9RMC3 , UniProt:Q9UZI7 , UniProt:Q9X364 , UniProt:Q9Z5G1 , UniProt:Q9ZLI8 , UniProt:Q05852 , UniProt:Q07130 , UniProt:Q07131 , UniProt:Q43772 , UniProt:Q46768 , UniProt:Q48447 , UniProt:Q58730

Relationship Links: BRENDA:EC:2.7.7.9 , ENZYME:EC:2.7.7.9 , IUBMB-ExplorEnz:EC:2.7.7.9 , UniProt:RELATED-TO:O05576 , UniProt:RELATED-TO:O25363 , UniProt:RELATED-TO:O26731 , UniProt:RELATED-TO:O51225 , UniProt:RELATED-TO:O67602 , UniProt:RELATED-TO:P08800 , UniProt:RELATED-TO:P0AAB6 , UniProt:RELATED-TO:P0AEP3 , UniProt:RELATED-TO:P19595 , UniProt:RELATED-TO:P27897 , UniProt:RELATED-TO:P32861 , UniProt:RELATED-TO:P33696 , UniProt:RELATED-TO:P37776 , UniProt:RELATED-TO:P44878 , UniProt:RELATED-TO:P47691 , UniProt:RELATED-TO:P74969 , UniProt:RELATED-TO:P75124 , UniProt:RELATED-TO:P78811 , UniProt:RELATED-TO:Q9PMD3 , UniProt:RELATED-TO:Q9RMC3 , UniProt:RELATED-TO:Q9UZI7 , UniProt:RELATED-TO:Q9X364 , UniProt:RELATED-TO:Q9Z5G1 , UniProt:RELATED-TO:Q9ZLI8 , UniProt:RELATED-TO:Q05852 , UniProt:RELATED-TO:Q07130 , UniProt:RELATED-TO:Q07131 , UniProt:RELATED-TO:Q43772 , UniProt:RELATED-TO:Q46768 , UniProt:RELATED-TO:Q48447 , UniProt:RELATED-TO:Q58730

Credits:
Created 18-Jun-2010 by Pujar A , Boyce Thompson Institute


References

Dai06: Dai N, Petreikov M, Portnoy V, Katzir N, Pharr DM, Schaffer AA (2006). "Cloning and expression analysis of a UDP-galactose/glucose pyrophosphorylase from melon fruit provides evidence for the major metabolic pathway of galactose metabolism in raffinose oligosaccharide metabolizing plants." Plant Physiol 142(1);294-304. PMID: 16829585

KALCKAR: KALCKAR HM "The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides." Biochim Biophys Acta 12(1-2);250-64. PMID: 13115434

Kamogawa65: Kamogawa A, Kurahashi K (1965). "Purification and properties of uridinediphosphate glucose pyrophosphorylase from Escherichia coli K12." J Biochem 57(6);758-65. PMID: 4284510

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

LobelleRich83: Lobelle-Rich PA, Reeves RE (1983). "Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica." Mol Biochem Parasitol 7(2);173-82. PMID: 6304512

SMITH55: SMITH EE, MILLS GT (1955). "The uridyl transferase of mammary gland." Biochim Biophys Acta 18(1);152. PMID: 13260264

Turnquist74: Turnquist RL, Gillett TA, Hansen RG (1974). "Uridine diphosphate glucose pyrophosphorylase. Crystallization and properties of the enzyme from rabbit liver and species comparisons." J Biol Chem 249(23);7695-700. PMID: 4436332


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc12.