MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: adenylosuccinate lyaseInferred from experiment: purB
Homo sapiens: adenylosuccinate lyaseInferred from experiment: ADSL
Methanocaldococcus jannaschii: adenylosuccinate lyaseAuthor statement: MJ0929
Saccharomyces cerevisiae: adenylosuccinate lyaseInferred from experiment: ade13

In Pathway: adenosine ribonucleotides de novo biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: adenylosuccinate lyase

Enzyme Commission Synonyms: adenylosuccinase, succino AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 55.0455Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole.

Citations: [CARTER56]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01083, Rhea:16853

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O65180, UniProt:RELATED-TO:P0AB89, UniProt:RELATED-TO:P12047, UniProt:RELATED-TO:P21265, UniProt:RELATED-TO:Q9CF40, UniProt:RELATED-TO:Q9JSP3, UniProt:RELATED-TO:Q9PJ88, UniProt:RELATED-TO:Q58339


CARTER56: CARTER CE, COHEN LH (1956). "The preparation and properties of adenylosuccinase and adenylosuccinic acid." J Biol Chem 222(1);17-30. PMID: 13366975

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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