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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
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MetaCyc Enzyme: phenylacrylate decarboxylase

Gene: pad1 Accession Number: G-442 (MetaCyc)

Synonyms: phenylacrylic acid decarboxylase

Species: Saccharomyces cerevisiae

Summary:
S. cerevisiae possesses the enzyme phenylacrylate decarboxylase (PAD) which confers resistance to cinnamate and other phenylacrylic acids. PAD decarboxylates ferulate, cinnamate and coumarate in that order of substrate preference [Goodey82, Clausen94].

Locations: cytoplasm

Molecular Weight of Polypeptide: 26.733 kD (from nucleotide sequence)

Unification Links: ArrayExpress:P33751 , DIP:DIP-5454N , Mint:MINT-503534 , ModBase:P33751 , Protein Model Portal:P33751 , SMR:P33751 , String:4932.YDR538W , Swiss-Model:P33751 , UniProt:P33751

Relationship Links: InterPro:IN-FAMILY:IPR003382 , InterPro:IN-FAMILY:IPR004507 , Panther:IN-FAMILY:PTHR14359:SF15 , Pfam:IN-FAMILY:PF02441

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005737 - cytoplasm


Enzymatic reaction of: trans-cinnamate decarboxylase (phenylacrylate decarboxylase)

EC Number: 4.1.1.-

trans-cinnamate + H+ <=> styrene + CO2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Reversibility of this reaction is unspecified.


Enzymatic reaction of: 4-coumarate decarboxylase (phenylacrylate decarboxylase)

Synonyms: phenylacrylate decarboxylase, hydroxycinnamate decarboxylase

EC Number: 4.1.1.-

4-coumarate + H+ <=> 4-vinylphenol + CO2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Reversibility of this reaction is unspecified.


Enzymatic reaction of: ferulate decarboxylase (phenylacrylate decarboxylase)

EC Number: 4.1.1.-

ferulate + H+ <=> 4-vinylguaiacol + CO2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.


References

Clausen94: Clausen M, Lamb CJ, Megnet R, Doerner PW (1994). "PAD1 encodes phenylacrylic acid decarboxylase which confers resistance to cinnamic acid in Saccharomyces cerevisiae." Gene 1994;142(1);107-12. PMID: 8181743

Goodey82: Goodey, AR, Tubb, RS (1982). "Genetic and biochemical analysis of the ability of Saccharaomyces cerevisiae to decarboxylate cinnamic acids." Journal of General Microbiology 128:2615-2620.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc12.