Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: phenylacrylate decarboxylase

Gene: pad1 Accession Number: G-442 (MetaCyc)

Synonyms: phenylacrylic acid decarboxylase

Species: Saccharomyces cerevisiae

Summary:
S. cerevisiae possesses the enzyme phenylacrylate decarboxylase (PAD) which confers resistance to cinnamate and other phenylacrylic acids. PAD decarboxylates ferulate, cinnamate and coumarate in that order of substrate preference [Goodey82, Clausen94].

Locations: cytoplasm

Molecular Weight of Polypeptide: 26.733 kD (from nucleotide sequence)

Unification Links: ArrayExpress:P33751 , DIP:DIP-5454N , Mint:MINT-503534 , ModBase:P33751 , Protein Model Portal:P33751 , SMR:P33751 , String:4932.YDR538W , Swiss-Model:P33751 , UniProt:P33751

Relationship Links: InterPro:IN-FAMILY:IPR003382 , InterPro:IN-FAMILY:IPR004507 , Panther:IN-FAMILY:PTHR14359:SF15 , Pfam:IN-FAMILY:PF02441

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005737 - cytoplasm


Enzymatic reaction of: trans-cinnamate decarboxylase (phenylacrylate decarboxylase)

EC Number: 4.1.1.-

trans-cinnamate + H+ <=> styrene + CO2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Reversibility of this reaction is unspecified.


Enzymatic reaction of: 4-coumarate decarboxylase (phenylacrylate decarboxylase)

Synonyms: phenylacrylate decarboxylase, hydroxycinnamate decarboxylase

EC Number: 4.1.1.-

4-coumarate + H+ <=> 4-vinylphenol + CO2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Reversibility of this reaction is unspecified.


Enzymatic reaction of: ferulate decarboxylase (phenylacrylate decarboxylase)

EC Number: 4.1.1.-

ferulate + H+ <=> 4-vinylguaiacol + CO2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.


References

Clausen94: Clausen M, Lamb CJ, Megnet R, Doerner PW (1994). "PAD1 encodes phenylacrylic acid decarboxylase which confers resistance to cinnamic acid in Saccharomyces cerevisiae." Gene 1994;142(1);107-12. PMID: 8181743

Goodey82: Goodey, AR, Tubb, RS (1982). "Genetic and biochemical analysis of the ability of Saccharaomyces cerevisiae to decarboxylate cinnamic acids." Journal of General Microbiology 128:2615-2620.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.